Why did early research on mRNA not gain global attention?
Posted: Wed Jan 08, 2025 3:59 am
After the 1960s, scientists began to understand the process of "DNA→mRNA→protein" more and more thoroughly. Many scientists began to try to put foreign DNA or mRNA directly into target cells, trying to turn cells into biochemical cells that serve scientists. The factory produces various proteins with specific functions by itself, directly regulating biochemical reactions in the body.
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But as mentioned earlier, compared to stable DNA molecules, mRNA is not only sensitive to heat, but is also easily detected by enzymes in tissues or the Toll-like receptors/TLRs system in the human body. Further decomposition can even easily induce severe inflammatory reactions. Therefore, the mainstream of the scientific community has long abandoned the use of mRNA for treatment, believing that although the use of mRNA for treatment is theoretically feasible, it will still be an impossible task if the existing shortcomings cannot be overcome.
Unpopular research on the underappreciated mRNA, encounter with scientists who are at a low ebb
But Carrico never gave up on the possibility of using mRNA for india telegram treatment. Carrico, who is from Hungary, immigrated to the United States in 1985. After listening to a lecture on mRNA at university, he has been obsessed with the interesting mechanism of RNA, thus starting a research path that has lasted for nearly 40 years. After becoming a researcher, the research topic has been focused on the fields of RNA and chemical synthesis, but the research process has not been smooth.
In 1990, Carrico applied for several research projects to the University of Pennsylvania, where he worked, but was rejected, and the research also stalled. Five years later, due to the lack of breakthroughs in her research, the University of Pennsylvania demoted Carrico from associate professor to assistant professor. She even suffered from cancer and was separated from her husband. Both her academic career and her life suffered a painful low point.
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But as mentioned earlier, compared to stable DNA molecules, mRNA is not only sensitive to heat, but is also easily detected by enzymes in tissues or the Toll-like receptors/TLRs system in the human body. Further decomposition can even easily induce severe inflammatory reactions. Therefore, the mainstream of the scientific community has long abandoned the use of mRNA for treatment, believing that although the use of mRNA for treatment is theoretically feasible, it will still be an impossible task if the existing shortcomings cannot be overcome.
Unpopular research on the underappreciated mRNA, encounter with scientists who are at a low ebb
But Carrico never gave up on the possibility of using mRNA for india telegram treatment. Carrico, who is from Hungary, immigrated to the United States in 1985. After listening to a lecture on mRNA at university, he has been obsessed with the interesting mechanism of RNA, thus starting a research path that has lasted for nearly 40 years. After becoming a researcher, the research topic has been focused on the fields of RNA and chemical synthesis, but the research process has not been smooth.
In 1990, Carrico applied for several research projects to the University of Pennsylvania, where he worked, but was rejected, and the research also stalled. Five years later, due to the lack of breakthroughs in her research, the University of Pennsylvania demoted Carrico from associate professor to assistant professor. She even suffered from cancer and was separated from her husband. Both her academic career and her life suffered a painful low point.